Antidepressant agents
Clinical Indications
Medication action
Drug interactions
Drug Interactions with SSRI | |
Interacting Drugs | Adverse effects |
Buspirone (BuSpar), TCA’s (especially clomipramine), Selegiline (Eldepryl), Saint John’s Wort | Serotonin syndrome |
MAOI’s | Hypertensive crisis |
Warfarin, NSAID’s | Increased risk of bleeding |
Alcohol, benzodiazepines | Increased sedation |
Antiepileptics | Lowered seizure threshold |
Drug Interaction with TCA’s | |
Interacting Drugs | Adverse effects |
MAOI’s | High fever, convulsions, death |
Saint John’s Wort, tramadol (Ultram) | Seizures, serotonin syndrome |
Clonidine (Catapres), epinephrine | Severe hypertension |
Acetylcholine blockers | Paralytic ileus |
Alcohol and carbamezipine (Tegretol) | Block antidepressant action, increases sedation |
Cimetidine (Tagamet), bupropion (BuSpar) | Increased TCA blood levels, increased side effects |
Drug Interactions with MAOI’s | |
Interacting Drugs | Adverse effects |
SSRI’s, TCA’s, atomoxetine (Strattera), duloxetine (Cymbalta), dextromethorphan (an ingredient in many cough syrups), venlafaxine (Effexor), St. John’s Wort, Ginkgo | Serotonin syndrome |
Morphine and other narcotic pain relievers, antihypertensive | Hypotension |
All other antidepressants, pseudoephedrine, amphetamines, cocaine cyclobenzaprine (Flexeril), dopamine, methyldopa, levodopa, epinephrine, buspirone (BuSpar) | Hypertensive crisis (these side effects can occur even if take with 2 weeks of stopping MAOI’s) |
Buspirone (BuSpar) | Psychosis, agitation, seizures |
Antidiabetics | Hypoglycemia |
Tegretol | Fever, hypertension, seizures |
Nursing diagnosis