Drug trade/ Generic names
Tofranil (Imipramine) Pamelor (Nortriptyline).
Blocks re-uptake of serotonin and nor-epinephrine.
Anti-cholinergic effects : dry mouth, blurred vision, urinary retention, sedation, and drowsiness
Not a first line treatment! Can overdose on these, and can cause cardiac conduction disturbances.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Celexa (Citalopram), Lexapro (Escitalopram), Luvox (Fluvoxamine)
(Most widely prescribed)
Blocks the re-uptake and thus the destruction of serotonin.
Apathy and low libido.
Difficult to overdose.
Serotonin- Norepinephrine Reuptake Inhibitors (SNRIs)
In low doses blocks reuptake of Serotonin; in high doses blocks reuptake of Norepinephrine
Monoamine Oxidase Inhibitors (MAOIs)
Marplan (Isocarboxazid), Nardil (Phenelzine), Parnate (Tranylcpromine) Ensam (Selegiline).
Inhibits the action of Monoamine Oxidase (Oxidase destroys Monoamines such as Serotonin, Epinephrine, Dopamine, and Norepinephrine).
Do not take with other anti-depressants
Avoid foods containing tyramine such as wine, smoked fish and aged cheese!
Toxic effect can develop into hypertensive crisis. (headache, increased respirations, light headed, vomiting, and increased heart rate)
If so, hold med, call MD, and take client to the ER
Lithium, anticonvulsant medications, and second-generation atypical antipsychotics
Common causes for Increased Lithium levels
Educate client and family about the medication